5-cyano-furan-2-carboxylic acid [5-hydroxymethyl-2-(4-methyl-piperidin-1-yl)-phenyl]-amide

This compound is a synthetic small molecule inhibitor known as cFMS-IN-2, designed to target the macrophage colony-stimulating factor 1 receptor (CSF1R, also called c-Fms). It belongs to the class of organic compounds known as 2-furanilides and features a furan ring with cyano and carboxamide substituents linked to a substituted phenyl group. The primary mechanism of action is inhibition of CSF1R kinase activity, which plays a key role in regulating macrophage proliferation and survival. This makes it relevant for research into diseases involving macrophages or CSF1R signaling, such as certain cancers or inflammatory conditions. The compound has not been approved for clinical use and remains experimental[1][2][10].

Other names

5-cyano-furan-2-carboxylic acid (5-hydroxymethyl-2-(4-methyl-piperidin-1-YL)-phenyl)-amideDB07167DB-07167DB 07167791587-67-2